MBC
1-乙基-2-((Z)-((Z)-3-乙基-5-(3-甲基苯并[d]噻唑-2(3H)-亚基)-4-氧代噻唑烷-2-亚基)甲基)吡啶-1-鎓氯化物|MKT077
| PB00279-1mg
纯度:95% ； 分子式:C21H22ClN3OS2
![1-乙基-2-((Z)-((Z)-3-乙基-5-(3-甲基苯并[d]噻唑-2(3H)-亚基)-4-氧代噻唑烷-2-亚基)甲基)吡啶-1-鎓氯化物](/upload/product/cas/600/147366-41-4.jpg)
M0703-74346
PB00279-1mg
1mg
147366-41-4
C21H22ClN3OS2
95%
¥946.00
¥946.00
1
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- 产品详情
昀冠品质提供的1-乙基-2-((Z)-((Z)-3-乙基-5-(3-甲基苯并[d]噻唑-2(3H)-亚基)-4-氧代噻唑烷-2-亚基)甲基)吡啶-1-鎓氯化物 MBC(PB00279-1mg) 性能卓越，竭诚为您服务。
| 英文名称* | MKT077 |
|---|---|
| 中文名称 | 1-乙基-2-((Z)-((Z)-3-乙基-5-(3-甲基苯并[d]噻唑-2(3H)-亚基)-4-氧代噻唑烷-2-亚基)甲基)吡啶-1-鎓氯化物 |
| 别名 | MKT 077, MKT-077, FJ-776, MKT-077, MKT 077 FJ-776 |
| 产品描述 | MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 µM in vitro) through its ability to inhibit members of the Hsp70 family of molecular chaperones. |
| 靶点活性 | HSP70 |
| 体外活性 | MKT-077 treatment (0.1-10 µM) for 48 hours can effectively decrease TT cell viability. MKT-077 treatment results in the accumulation of cells in the G0/G1 phase in a dose-dependent manner, and also increases the sub-G0/G1 phase population in TT cell culture in a dose-dependent manner. MKT-077 also downregulates cellular levels of the proliferation marker, Ki67, and the S-phase transcription factor, E2F-1, in TT and MZ-CRC-1 cells. Moreover, TT cells can uptake and retain MKT-077 at significantly higher levels than MZ-CRC-1 cells [1]. MKT-077 has EC50 values of 1.4±0.2 and 2.2±0.2 μM against MCF7 and MDA-MB-231 breast cancer cells, respectively [2]. |
| 体内活性 | Systemic administration of MKT-077 significantly delayed the growth of TT xenografts in mice throughout the treatment. At the end of the drug treatment, we found that tumor weights were about two-timed less in MKT-077-treated group than in the control group. These data are consistent with the growth inhibitory effects of MKT-077 observed in the in vitro setting above [1]. The succinate-induced, ADP-stimulated respiratory rate in mitochondria isolated from the liver of rats treated with a bolus i.v. injection of 15 mg MKT-077 1kg body weight each day for 5 days is significantly lower than that of untreated controls [3]. |
| CAS | 147366-41-4 |
| 纯度 | 95% |
| 分子量 | 432 |
| 分子式 | C21H22ClN3OS2 |
| 溶解度 | DMSO: 20 mg/mL Water: 20 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
| 储存温度 | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| 品牌 | MBC |
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