MBC
3-(1-((3,3-二苯丙基)(甲基)氨基)-2-甲基丙-2-基) 5-甲基 2,6-二甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯盐酸盐|Lercanidipine hydrochloride
| PB00001-50mg
純度: 99+%
M0703-73350
PB00001-50mg
50mg
132866-11-6
C36H41N3O6·HCl
99+%
¥276.00
¥90.00
1
3 天
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昀冠品质提供的3-(1-((3,3-二苯丙基)(甲基)氨基)-2-甲基丙-2-基) 5-甲基 2,6-二甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯盐酸盐 MBC(PB00001-50mg) 性能卓越，竭诚为您服务。
| 英文名称* | Lercanidipine hydrochloride |
|---|---|
| 中文名称 | 3-(1-((3,3-二苯丙基)(甲基)氨基)-2-甲基丙-2-基) 5-甲基 2,6-二甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯盐酸盐 |
| 别名 | Cardiovasc, Carmen, Corifeo, Corifeo, Carmen, Cardiovasc |
| 产品描述 | Lercanidipine is a calcium channel blocker of the dihydropyridine class. |
| 靶点活性 | Calcium Channel |
| 体外活性 | In vitro calcium antagonistic activity of Lercanidipine is clearly related to a gradual block of calcium entry into smooth muscle cells via L-type calcium channels. lercanidipine inhibits cellular cholesteryl ester formation. At concentrations similar to those occurring in clinical practice, it may inhibit in vitro macrophage functions involved in atherogenesis and plaque stability[1]. |
| 体内活性 | In chronically catheterised dogs with experimental renovascular hypertension, lercanidipine decreases diastolic blood pressure in a dose-dependent manner (ED25 = 0.9 mg/kg p.o). In the same animals, long term application of lercanidipine showed permanent decrease of diastolic blood pressure indicating no tolerance of the antihypertensive effect[3]. Lercanidipine possesses significant anticonvulsant effect. It does not affect the muscle coordination or locomotor activity in mice[5]. In clinical studies, lercanidipine has a 24-hour antihypertensive effect and causes no significant increase in heart rate. Lercanidipine has been shown to be effective in a wide range of hypertensive patients, including mild-to-moderate hypertension, severe hypertension, the elderly, and those with isolated systolic hypertension. It is associated with a low rate of adverse events[4]. |
| 细胞实验 | Cells are incubated for 24 hours in DMEM+EFAF 0.2% and lercanidipine, then with lercanidipine and AcLDL for 24 hours. In the last 2 hours [14C]-oleic acid albumin complex is added for the determination of cholesterol esterification (ACAT activity). (Only for Reference) Cell lines: Mouse peritoneal macrophages |
| CAS | 132866-11-6 |
| 纯度 | 99+% |
| 分子量 | 648.19 |
| 分子式 | C36H41N3O6·HCl |
| 溶解度 | DMSO: 64.8 mg/mL (100 mM) Ethanol: 6.5 mg/mL (10 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
| 储存温度 | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| 品牌 | MBC |
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